Publications

G. Bashiri

F420-dependent transformations in biosynthesis of secondary metabolites

Current Opinion in Chemical Biology. 80:102468 (2024)

Bashiri G, Bulloch EMM, Bramley WR, Davidson M, Stuteley SM, Young PG, Harris PWR, Naqvi MSH, Middleditch MJ, Schmitz M, Chang W, Baker EN and CJ Squire

Poly‐γ‐glutamylation of biomolecules 

Nature Communications. 15:1310 (2024)

Abrahams KA, Batt S, Gurcha SS, Veerapen N, Bashiri G and G Besra

DprE2 is a novel molecular target of the anti-tubercular nitroimidazole compounds, pretomanid and delamanid

Nature Communications.14:3828 (2023)

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Zhu HJ, Zhang B, Liu SH, Xiang L, Wang W, Zhu J, Jiao RH, Igarashi Y, Bashiri G, Tan RX and HM Ge

AvmM catalyses macrocyclization through dehydration/Michael-type addition in Alchivemycin A biosynthesis

Nature Communications. 13:4499 (2022) 

Chandra DB, Zhang W, Yang C, Mándi CA, Huang C, Zhang L, Liu W, Ruszczycky MW, Zhu Y, Ma M, Bashiri G, Kurtán T, Liu HW and C Zhang

Flavin-enabled reductive and oxidative epoxide ring opening reactions

Nature Communications. 13:4896 (2022)

Barra L, Awakawa T, Shirai K, Hu Z, Bashiri G and I Abe​

β-NAD as a building block in natural product biosynthesis

Nature. 600: 754-758 (2021)

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Zhu HJ, Zhang B, Wang L, Wang W, Liu SH, Igarashi Y, Bashiri G, Tan RX and HM Ge

A metabolic redox network in the biosynthesis of Alchivemycin A enables formation of its key pharmacophore

Journal of the American Chemical Society. 143: 4751-4757 (2021)

Xu M, Zhang F, Cheng Z, Bashiri G, Chen X, Wang Y, Xu L, Huang S, Lin S, Deng Z and M Tao

Functional genome mining reveals a novel class V lanthipeptide with unique D-amino acid introduction by an F420H2-dependent reductase 

Angewandte Chemie International Edition. 59: 18029-18035 (2020)

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Bashiri G and EN Baker

Convergent pathways to biosynthesis of the versatile cofactor F420

Current Opinion in Structural Biology. 65: 9-16 (2020)

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Bashiri G, Nigon L, Jirgis ENM, Ho T, Stanborough T, Dawes S, Baker EN, Bulloch EMM and JM Johnston 

Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis

Journal of Biological Chemistry. 295: 3759-3770 (2020) 

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Steiningerova L, Kamenik Z, Gažák R, Kadlcik S, Bashiri G, Man P, Pavlikova M and J Janata 

Different reaction specificities of F420H2-dependent reductases facilitate pyrrolobenzodiazepines and lincomycin to fit their biological targets

Journal of the American Chemical Society. 142, 7, 3440-3448 (2020)

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Bhusal RP, Jiao W, Swartjes A, Kwai BXC, Patel K, Reynisson J, Sperry J, Bashiri G and IKH Leung 

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Nature Communications.10:4639 (2019)

Bashiri G, Grove TL, Hegde SS, Lagautriere T, Gerfen G, Almo SC, Squire C, Blanchard JS and EN Baker 

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

Journal of Biological Chemistry. 294:13158-13170 (2019) 

Bashiri G, Antoney J, Jirgis ENM, Ney B, Sreebhavan S, Palmer B, Middleditch M, Greening C, Scott C, Baker EN and C Jackson 

A revised biosynthetic pathway for the cofactor F420 in prokaryotes

Nature Communications. 10:1558 (2019) 

Ichikawa H, Bashiri G and WL Kelly 

Biosynthesis of the thiopeptins and identification of an F420H2‑dependent dehydropiperidine reductase

Journal of the American Chemical Society. 140:10749-10756 (2018) 

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Full list of publications