Publications

Zhu HJ, Zhang B, Wang L, Wang W, Liu SH, Igarashi Y, Bashiri G, Tan RX and HM Ge

A metabolic redox network in the biosynthesis of Alchivemycin A enables formation of its key pharmacophore. 

Journal of the American Chemical Society. 143: 4751-4757 (2021)


Xu M, Zhang F, Cheng Z, Bashiri G, Chen X, Wang Y, Xu L, Huang S, Lin S, Deng Z and M Tao

Functional genome mining reveals a novel class V lanthipeptide with unique D-amino acid introduction by an F420H2-dependent reductase. 

Angewandte Chemie International Edition. 59: 18029-18035 (2020)


Bashiri G and EN Baker

Convergent pathways to biosynthesis of the versatile cofactor F420. 

Current Opinion in Structural Biology. 65: 9-16 (2020)


Bashiri G, Nigon L, Jirgis ENM, Ho T, Stanborough T, Dawes S, Baker EN, Bulloch EMM and JM Johnston 

Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis

Journal of Biological Chemistry. 295: 3759-3770 (2020) 


Steiningerova L, Kamenik Z, Gažák R, Kadlcik S, Bashiri G, Man P, Pavlikova M and J Janata 

Different reaction specificities of F420H2-dependent reductases facilitate pyrrolobenzodiazepines and lincomycin to fit their biological targets. 

Journal of the American Chemical Society. 142, 7, 3440-3448 (2020)


Bhusal RP, Jiao W, Swartjes A, Kwai BXC, Patel K, Reynisson J, Sperry J, Bashiri G and IKH Leung 

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.

Nature Communications.10:4639 (2019)


Bashiri G, Grove TL, Hegde SS, Lagautriere T, Gerfen G, Almo SC, Squire C, Blanchard JS and EN Baker 

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster. 

Journal of Biological Chemistry. 294:13158-13170 (2019) 


Bashiri G, Antoney J, Jirgis ENM, Ney B, Sreebhavan S, Palmer B, Middleditch M, Greening C, Scott C, Baker EN and C Jackson 

A revised biosynthetic pathway for the cofactor F420 in prokaryotes. 

Nature Communications. 10:1558 (2019) 


Ichikawa H, Bashiri G and WL Kelly 

Biosynthesis of the thiopeptins and identification of an F420H2‑dependent dehydropiperidine reductase

Journal of the American Chemical Society. 140:10749-10756 (2018) 

Full list of publications