Publications

Mo J, Sikandar A, Zhao H, Bashiri G, Huo L, Empting M, Müller R and C Fu
Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2-dependent statine pathway
Nature Communications. 16:4531 (2025)

G. Bashiri
F420-dependent transformations in biosynthesis of secondary metabolites
Current Opinion in Chemical Biology. 80:102468 (2024)
 
Bashiri G, Bulloch EMM, Bramley WR, Davidson M, Stuteley SM, Young PG, Harris PWR, Naqvi MSH, Middleditch MJ, Schmitz M, Chang W, Baker EN and CJ Squire
Poly‐γ‐glutamylation of biomolecules 
Nature Communications. 15:1310 (2024)
 
Abrahams KA, Batt S, Gurcha SS, Veerapen N, Bashiri G and G Besra
DprE2 is a novel molecular target of the anti-tubercular nitroimidazole compounds, pretomanid and delamanid
Nature Communications.14:3828 (2023)
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Zhu HJ, Zhang B, Liu SH, Xiang L, Wang W, Zhu J, Jiao RH, Igarashi Y, Bashiri G, Tan RX and HM Ge
AvmM catalyses macrocyclization through dehydration/Michael-type addition in Alchivemycin A biosynthesis
Nature Communications. 13:4499 (2022) 
 
Chandra DB, Zhang W, Yang C, Mándi CA, Huang C, Zhang L, Liu W, Ruszczycky MW, Zhu Y, Ma M, Bashiri G, Kurtán T, Liu HW and C Zhang
Flavin-enabled reductive and oxidative epoxide ring opening reactions
Nature Communications. 13:4896 (2022)
 
Barra L, Awakawa T, Shirai K, Hu Z, Bashiri G and I Abe​
β-NAD as a building block in natural product biosynthesis
Nature. 600: 754-758 (2021)
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Zhu HJ, Zhang B, Wang L, Wang W, Liu SH, Igarashi Y, Bashiri G, Tan RX and HM Ge
A metabolic redox network in the biosynthesis of Alchivemycin A enables formation of its key pharmacophore
Journal of the American Chemical Society. 143: 4751-4757 (2021)
 
Xu M, Zhang F, Cheng Z, Bashiri G, Chen X, Wang Y, Xu L, Huang S, Lin S, Deng Z and M Tao
Functional genome mining reveals a novel class V lanthipeptide with unique D-amino acid introduction by an F420H2-dependent reductase 
Angewandte Chemie International Edition. 59: 18029-18035 (2020)
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Bashiri G and EN Baker
Convergent pathways to biosynthesis of the versatile cofactor F420
Current Opinion in Structural Biology. 65: 9-16 (2020)
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Bashiri G, Nigon L, Jirgis ENM, Ho T, Stanborough T, Dawes S, Baker EN, Bulloch EMM and JM Johnston 
Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis
Journal of Biological Chemistry. 295: 3759-3770 (2020) 
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Steiningerova L, Kamenik Z, Gažák R, Kadlcik S, Bashiri G, Man P, Pavlikova M and J Janata 
Different reaction specificities of F420H2-dependent reductases facilitate pyrrolobenzodiazepines and lincomycin to fit their biological targets
Journal of the American Chemical Society. 142, 7, 3440-3448 (2020)
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Bhusal RP, Jiao W, Swartjes A, Kwai BXC, Patel K, Reynisson J, Sperry J, Bashiri G and IKH Leung 
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
Nature Communications.10:4639 (2019)
 
Bashiri G, Grove TL, Hegde SS, Lagautriere T, Gerfen G, Almo SC, Squire C, Blanchard JS and EN Baker 
The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster
Journal of Biological Chemistry. 294:13158-13170 (2019) 
 
Bashiri G, Antoney J, Jirgis ENM, Ney B, Sreebhavan S, Palmer B, Middleditch M, Greening C, Scott C, Baker EN and C Jackson 
A revised biosynthetic pathway for the cofactor F420 in prokaryotes
Nature Communications. 10:1558 (2019) 
 
Ichikawa H, Bashiri G and WL Kelly 
Biosynthesis of the thiopeptins and identification of an F420H2‑dependent dehydropiperidine reductase
Journal of the American Chemical Society. 140:10749-10756 (2018) 
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Full list of publications